一對十二歲的雙胞胎男孩 Zack(Dylan Sprouse)和Cody(Cole Sprouse)還有他們的媽媽是這所波斯頓高檔Tipton酒店的長期住客。在這裏，他們認識了新朋友London(Brenda Song)和Maddie(Ashley Tisdale)。Zack和Cody接二連三的惡作劇把Tipton旅館變成了他們的遊樂場。在搞笑、搗蛋、引發混亂的同時，也帶著London和 Maddie瘋了一回。

　　Outrageous shenanigans ensue when 12-year-old twin boys Zack (Dylan Sprouse) and Cody (Cole Sprouse) turn the upscale Boston hotel where they live (The Tipton) into their own personal playground. Living in a suite with their mom Carey, the boys often take their new friends London and Maddie along for the ride, as they cause mischief, mayhem, and various catastrophes in their elegant new digs.